Clinical trial shows gabapentin effective for alcohol dependence

Gabapentin, already widely prescribed for epilepsy and pain, appears to be safe and effective in the treatment of alcohol dependence, studies have found.

Scientists at The Scripps Research Institute (TSRI) conducted a 150-patient randomized, placebo-controlled, double blind clinical trial, with the results published in JAMA Internal Medicine on November 4 and reported by Eurek Alert.

Barbara Mason, Pearson Family Professor and co-director of the Pearson Center for Alcoholism and Addiction Research at TSRI, who led the new research, said: “Gabapent's effect on drinking outcomes is at least as large or greater than those of existing FDA [Food and Drug Administration]-approved treatments. Plus it’s the only medication shown to improve sleep and mood in people who are quitting or reducing their drinking, and it's already widely used in primary care – that's an appealing combination.”