Biohaven shares hold up despite top-line failure

25 November 2024

US biopharma Biohaven has provided an update regarding the taldefgrobep alfa development programs in spinal muscular atrophy (SMA) and obesity. 

In the RESILIENT SMA study, taldefgrobep alpha showed-clinically meaningful improvements in motor function at all timepoints on the motor function measurement-32 scale (MFM-32), but the treatment arm did not statistically separate on the primary outcome at week 48 compared to the placebo and standard of care (SOC) group.

Majority subgroup showed benefit

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