Cassava crashes as Alzheimer’s dream dies
Cassava Sciences (Nasdaq: SAVA), a US biotech developing a novel, investigational treatment for Alzheimer’s disease (AD) dementia, was trading 83% lower at midday on Thursday.
The company earlier announced that the top-line results from the Phase III ReThink-ALZ study of simufilam in mild-to-moderate AD did not meet each of the pre-specified co-primary, secondary and exploratory biomarker endpoints.
The co-primary endpoints were the change in cognition and function from baseline to the end of the double-blind treatment period at week 52, comparing the oral small molecule that targets the filamin A protein, to placebo.
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