'Compelling' results for AbbVie's Teliso-V in lung cancer

30 November 2023

Top-line results from the single-arm Phase II LUMINOSITY trial evaluating telisotuzumab-vedotin (Teliso-V) in patients with c-Met protein overexpression, epidermal growth factor receptor (EGFR) wild type, advanced/metastatic non-squamous non-small cell lung cancer (NSCLC) have been released by AbbVie (NYSE: ABBV).

The Chicago, USA-based drug maker said the results demonstrated a compelling overall response rate per independent central review (ICR) of 35% and 23% across c-Met High and c-Met Intermediate patients respectively. Teliso-V, an investigational ADC, is being studied in this patient population who have very limited treatment options and where there are currently no approved therapies.

In addition, other endpoints demonstrated meaningful clinical outcomes including median duration of response per ICR of 9 months and 7.2 months and a median overall survival of 14.6 months and 14.2 months across c-Met High and c-Met Intermediate patients respectively.

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