Antibody-drug conjugate falls in late stage testing in glioblastoma

17 May 2019

The Phase III INTELLANCE-1 study has missed its primary endpoint, Chicago-based AbbVie (NYSE: ABBV) reported on Friday morning.

The trial has been investigating Depatux-M (depatuxizumab mafodotin), previously known as ABT-414, in certain people with newly diagnosed glioblastoma (GBM).

After the trial showed no survival benefit at an interim analysis, an Independent Data Monitoring Committee recommended the study be stopped, and enrollment has been halted.

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