Pharmaceutical News last week on the clinical trial front included disappointing results with Vectura’s VR475 in asthma, causing the company to abandon further development of the drug. There was better news for Vertex, which presented positive data on its VX 659 in cystic fibrosis. Regulatory news included US Food and Drug Administration approval for Bayer and Loxo Oncology’s TRK inhibitor Vitrakvi in solid tumors. Elsewhere, Roche announced it is buying US biotech start-up Jecure Therapeutics, aiming to join the non-alcoholic steatohepatitis (NASH) race, and Moderna Therapeutics plans IPO valued at over $500 million, making it the largest ever development-stage biotech IPO. 2 December 2018