Transition Thera/Eli Lilly's abandon diabetes drug TT-223 after it fails to meet endpoints
Canada’s Transition Therapeutics that a clinical study of gastrin analogue TT-223 in combination with an Eli Lilly (NYSE: LLY) proprietary GLP-1 analogue in patients with type 2 diabetes did not meet its efficacy endpoints. Given these findings, there will be no further development of TT-223.
"Development of a disease modifying therapy for type 2 diabetes is a high risk endeavour, but one that is needed by the millions of people living with this disease, said Transition. While TT-223 has shown efficacy through development, these results indicate that it does not have the product profile for a diabetes therapy," said Tony Cruz, chairman and chief executive of Transition.
The study was a randomized, double-blind, placebo-controlled study in approximately 150 patients to evaluate the safety, tolerability and efficacy of daily TT-223 treatments in combination with weekly administrations of GLP-1 analogue, for a combination treatment period of 4 weeks with a 5-month follow-up.
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