Data backs Darzalex quadruplet therapy as foundational standard of care for NDMM

11 April 2025

Johnson & Johnson (NYSE: JNJ) has announced new data from an analysis modelling long-term progression free survival (PFS) in transplant eligible (TE) and transplant ineligible (TIE) newly diagnosed multiple myeloma (NDMM) patients given Darzalex (daratumumab)-subcutaneous (SC) therapy alongside bortezomib, lenalidomide and dexamethasone (VRd).

These data, which were presented at the 6th European Myeloma Network (EMN) meeting in Athens, Greece, reported that median PFS (mPFS) projections based on the PERSEUS and CEPHEUS trials were significantly longer with daratumumab-VRd regimens compared to VRd regimens.

A transformative, frontline therapy, regardless of transplant eligibility

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