Takeda's dengue vaccine candidate provides continued protection

Japan’s largest drugmaker Takeda (TYO: 4502) yesterday announced that its dengue vaccine candidate, TAK-003, prevented 84% of hospitalized dengue cases and 61% of symptomatic dengue cases, with no important safety risks identified, in the overall population including both seropositive and seronegative individuals through four and a half years (54 months) after vaccination in the pivotal Phase III Tetravalent Immunization against Dengue Efficacy Study (TIDES) trial.

These data were presented on June 9, 2022, at the 8th Northern European Conference on Travel Medicine (NECTM8), with plans to feature the results at additional upcoming conferences.

“The burden of dengue is far reaching, and over half of the world’s population is at risk of dengue each year,” said Dr  Eng Eong Ooi, Duke-NUS Medical School, Singapore, adding: “There is an urgent need for impactful prevention tools to combat the disease. The long-term TIDES results indicate that TAK-003 could be an important addition to the limited tools we have to prevent dengue, particularly given the demonstrated protection against hospitalizations.”