Potential treatment for painful side effect of diabetes unveiled by UK researchers

14 May 2012

An international team of scientists say that they have a deeper understanding of why diabetics suffer from increased pain and temperature sensitivity, which may lead to new treatment for those side effects of diabetes. Their report appeared in the journal Nature Medicine, May 13.

Painful diabetic neuropathy, which is abnormal and persistent pain experienced by roughly 50% of patients with diabetes, impairs patients' quality of life and affects sleep, mood, mobility, ability to work and self-esteem.

Currently there is no clear understanding of how abnormal glucose metabolism produces heightened pain in diabetics, but this study offers new insights. The team showed that a compound called methylglyoxal (MG), which is produced excessively from glucose in diabetes, is a new culprit in pain discomfort.

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