Plans for Armetheon's anticoagulant tecarfarin for patients with prosthetic heart valves or chronic renal dysfunction
Privately-held US drug developer Armetheon revealed on Friday that it plans to develop its novel oral anti-coagulant (OAC) tecarfarin for a patient population which includes those who have prosthetic heart valves or chronic renal dysfunction.
Tecarfarin (formerly ATI-5923) is a long-acting anticoagulant that inhibits vitamin K epoxide reductase (VKOR). Armetheon acquired the asset from the now-defunct ARYx Therapeutics last year.
In these patients, currently available OACs are contra-indicated or inadequate. Tecarfarin, a potentially best-in-class OAC, was designed to avoid cytochrome P450 (CYP) related metabolism that is a major cause of safety and efficacy problems related to the use of warfarin (Coumadin), the current standard of care.
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