Pfizer drops development of Trubion's RA drug TRU-015, but will continue with SB-087
US drug developer Trubion Pharmaceuticals says that partner Pfizer has decided to discontinue development of TRU-015 (PF-05212374), an investigational drug in Phase II evaluation for the treatment of rheumatoid arthritis (RA) developed under the companies' CD20 collaboration. However, global behemoth Pfizer has confirmed that it will continue to develop SBI-087 (PF-05230895), Trubion's next-generation, humanized, subcutaneous CD20 RA product candidate also in Phase II clinical evaluation.
Pfizer's decision is based on preliminary results from the Phase IIb (2203) randomized, parallel, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of two dosing regimens (a single dose of 800mg TRU-015 compared with an induction dose of 800mg TRU-015 followed by an additional dose of 800mg TRU-015 at week 12) in combination with methotrexate in patients with active rheumatoid arthritis.
Did not meet primary endpoint
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