Massachusetts, USA-based PerkinElmer has entered into a drug discovery research collaboration with Sangmyung University of South Korea, based on applying PerkinElmer's AequoScreen aequorin assay technology to cutting-edge G-protein coupled receptor research.
It is estimated that GPCRs are associated with at least 30% of addressable diseases, and continue to be a key focus in drug discovery. Aequorin assays are a sensitive and flexible cell-based assay technology used to detect GPCR activation with several advantages over conventional fluorescence-based dyes, including fewer false positives, much simpler protocol and significantly increased assay windows.
AequoScreen will be used by Sangmyung University as part of its efforts to establish an academic GPCR screening facility together with the Korea Chemical Bank, a national repository library of over 100,000 small-molecule compounds. The aequorin technology will be used as part of nationwide GPCR screening campaigns and drug discovery programs in Korea.
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