TxCell options rights to CAR-Treg program

10 July 2018

France’s TxCell (Euronext Paris: TXCL) announced late Monday that it has exercised its exclusive option to in-license the intellectual property rights of one of its academic partners, the University of British Columbia (UBC), onto the HLA-A2 CAR-Treg program.

This program, named TX200 in TxCell's portfolio, should soon be tested in humans in the prevention of chronic transplant rejection. A first clinical trial application (CTA) is expected to be actioned in Europe in the first part of 2019.

The product originated in the laboratories of Dr Megan Levings, UBC in Vancouver, Canada, who established the first preclinical proof of concept with human HLA-A2-specific CAR-Treg cells in a preclinical model of GvHD.

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