Syndax in-licenses portfolio of blood cancer candidates
US oncology-focussed biotech firm Syndax Pharmaceuticals (Nasdaq: SNDX) has entered into an exclusive worldwide license agreement with Vitae Pharmaceuticals, a subsidiary of Ireland-incorporated Allergan (NYSE: AGN), for a portfolio of preclinical, orally-available small molecule inhibitors of the interaction of Menin with the mixed lineage leukemia (MLL) protein.
These compounds have potential application in the treatment of a genetically-defined subset of acute leukemias with chromosomal rearrangements in the MLL gene (MLL-r). Syndax expects to initiate clinical studies in 2019. Syndax itself is developing entinostat (also in combination with Merck KGaA and Pfizer’s avelumab, as well as with Merck & Co’s Keytruda) and SNDX-6352 in multiple cancer indications.
Financial terms of the deal
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