US biologics specialist Repligen (Nasdaq: RGEN) revealed in a filing with the Securities and Exchange Commission that pharma giant Pfizer (NYSE: PFE) is terminating its 2012 agreement for the development of compounds to treat spinal muscular atrophy (SMA). The termination of the license agreement will become effective as of April 26, 2015.
Under the initial deal, Pfizer $5 million up front and committed to payments of a further $65 million in milestones to gain rights for RG3039, a Phase I drug designed to block enzyme DcpS and improve survival and motor function in SMA patients. Pfizer gave no reason for its decision.
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