Novel intrathecal catheterized models advance early stage development of neurological disease therapy

Intrathecal catheterization is a highly effective delivery method for drugs targeting neurological diseases, writes Brad Gien, head of surgery, North America, Envigo, in an Expert View piece.

Indeed, it is one of the few procedures that successfully overcomes the blood-brain barrier (BBB) issue to enable molecules to actually reach the central nervous system (CNS).

Furthermore, the one significant drawback to the method – the risk of causing a range of complications to rat models – can be reduced by CROs providing specially trained surgeons that possess the skill and knowledge to provide optimal precision in the administration of the procedure.