NICE draft guidance says 'No' to Roche's Gazyvaro

14 September 2016

The UK’s National Institute for Health and Care Excellence (NICE) has today published draft guidance that does not recommend Swiss pharma giant Roche’s (ROG: SIX) Gazyvaro/Gazyva (obinutuzumab) with bendamustine for treating some people with follicular lymphoma – a type of non-Hodgkin’s lymphoma.

Obinutuzumab with bendamustine is used to treat follicular lymphoma in people who did not respond to, or whose condition has progressed after treatment with, rituximab – containing regimens (current standard treatment that targets lymphoma cells).

The NICE appraisal committee concluded that there were uncertainties in the evidence for obinutuzumab with bendamustine which meant that the overall survival gain of patients was unclear, so could not recommend the drug as a cost-effective use of NHS resources. The committee noted that an updated analysis from the pivotal trial for the drug will soon be available.

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