Illuminating histiocytic neoplasms (histiocytosis)

25 January 2023
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By Dr Nicola Davies

Histiocytic neoplasms, also known as histiocytosis, are rare disorders in which specialized immune cells (histiocytes) accumulate and form tumors in tissues such as skin, bones, liver, lungs, lymph nodes and spleen.1,2

Initial presentations can vary, which often results in a delay in the diagnosis and treatment. Symptoms include abdominal pain, bone pain, delayed puberty, fever, rash, headache, frequent urination, mental decline, weight loss, seizures, and jaundice. Histiocytosis can occur at any age, although it occurs most often in children.1

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