Exelixis hurt by failure of Tecentriq and Cotellic combo

10 May 2018

The failure of the Phase III IMblaze370 study evaluating the combination of Tecentriq (atezolizumab) and Cotellic (cobimetinib) was bad news for Swiss pharma giant Roche (ROG: SIX) and its Genentech biotech unit, but worse for US biotech Exelixis (Nasdaq: EXEL).

Tecentriq represents Roche’s biggest near-term hope as a challenger in the immuno-oncology (I-O) space, and it is partnering with Exelixis on Cotellic, a MEK inhibitor.

"We will continue to work with Genentech on the evaluation of cobimetinib’s potential in other tumor types, including in melanoma, in which there are two ongoing Phase III pivotal trials"

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