The US and European (France, Germany, Italy, Spain and U.K.) sales of Roche/Biogen Idec's Rituxan/MabThera (rituximab), Bristol-Myers Squibb/Merck' KGaA's Erbitux (cetuximab) and Roche's Herceptin (trastuzumab) will peak at almost $16 billion in 2014, before falling to roughly $10 billion in 2018, according to forecasts by research and advisory firm Decision Resources. Biosimilars ' generic versions 'of these three branded agents are forecasted to erode $8.2 billion in US and European sales in 2018 but they are expected to capture only $4.6 billion in sales due to their lower prices.
"Biosimilars of the five brands covered in this report (Rituxan/MabThera, Erbitux, Herceptin, Amgen's Neupogen (filgrastim) and Neulasta (pegfilgrastim) will erode $34.3 billion in brand sales during our 2008-2018 forecast period across the USA and Europe and save health care systems $17.3 billion in the process," stated Michael Malecki, analyst and product manager at Decision Resources.
The new special report entitled Biosimilars: G-CSFs and Monoclonal Antibodies in Oncology also finds that oncologists are expected to demand clinical data for biosimilars demonstrating equivalence in multiple subpopulations. That is, although a biosimilar may be labeled for use in multiple sub-populations, oncologists will not feel comfortable prescribing a biosimilar without clinical validation.
Over time, oncologists are expected to become more comfortable using biosimilars in sub-populations and/or indications for which the reference product is approved but not clinically validated. In order to slow the growth of physician comfort in this regard, makers of branded biologics should emphasize the proven efficacy records of their agents and the importance of using a fully validated therapy for patients with life-threatening disease.
"Although surveyed oncologists are the most aggressive in treating cancers, they are hesitant to prescribe a biosimilar if it has not been clinically studied for the indication they are treating, even if the biosimilar is labeled for the indication in question," added Dr Malecki.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2024 | Headless Content Management with Blaze