Uncertain future for S1P receptor modulators in Crohn’s disease, says GlobalData

11 October 2024

Pfizer (NYSE: PFE) is to present initial findings from its CULTIVATE study of its sphingosine-1-phosphate (S1P) receptor modulator Velsipity (etrasimod) in Crohn’s disease (CD) at United European Gastroenterology Week 2024.

The results show only modest efficacy in endoscopic response and remission rates.

With its in-class competitor Zeposia (ozanimod) also underperforming in trials, the outlook for S1P receptor modulators in Crohn’s disease remains uncertain, highlighting challenges in addressing this complex condition, says GlobalData, the data and analytics company.

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