Sanofi and Denali drop Phase II oditrasertib trial

14 October 2024

Via a Securities and Exchange Commission (SEC) filing, US biotech Denali Therapeutics (Nasdaq: DNLI) disclosed the scrapping of a md-stage multiple sclerosis study

Denali stated that it has been informed by its strategic partner, French pharma major Sanofi (Euronext: SAN), that the K2 Phase II study evaluating the safety and efficacy of oditrasertib (SAR443820/DNL788) on serum neurofilament light chain levels in participants with multiple sclerosis was discontinued based on not meeting the primary and key secondary endpoints.

No specific details were provided in Denali’s SEC document, nor did the company identify which particular secondary outcomes oditrasertib missed. The biotech also did not address oditrasertib’s safety profile.

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