Takeda shuts down Ninlaro trial in AL amyloidosis

6 June 2019

Japanese drugmaker Takeda (TYO: 4502) has abandoned its Phase III TOURMALINE-AL1 trial in relapsed or refractory systemic light-chain (AL) amyloidosis.

The study did not meet the first of two primary endpoints, with Ninlaro (ixazomib) in combination with dexamethasone failing to demonstrate a significant improvement in overall hematologic response compared to physician’s choice of standard of care regimens.

Takeda’s study was one of the largest ever conducted in systemic light-chain AL amyloidosis, for which there are currently no treatments approved. It is closely related to multiple myeloma, another disease in which identical clones of antibody-producing cells grow rapidly.

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