NICE 'no' for short bowel syndrome drug Revestive

13 November 2017
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UK medicines cost-effectiveness watchdog the National Institute for Health and Care Excellence (NICE) has published draft guidance today that does not recommend Revestive (teduglutide) for treatment of people with short bowel syndrome (SBS).

The drug, from Ireland-headquartered Shire (LSE: SHP), is licensed for treating patients in a stable condition after their intestine has adapted post-surgery. SBS is a chronic condition relating to a reduced ability to absorb nutrients in the intestine.

Shire’s shares dipped 0.75% to 3,508 pence by mid-afternoon. Shire gained rights to Gattex/Revestive, as well as Natpara/Natpar (rhPTH [1-84]) for the treatment of hypoparathyroidism (HPT), when it acquired US firm NPS Pharmaceuticals in 2015 for a total consideration of around $5.2 billion. Gattex/Revestive (teduglutide) generated sales of $219 million in 2016, a year-on-year rise of 55%.

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