HIV drug nelfinavir shows efficacy in mouse models of HER2+ breast cancer
The HIV protease inhibitor nelfinavir, marketed by Swiss drug major Roche as Viracept, can be used to treat HER2-positive breast cancer in the same capacity and dosage regimen that it is used to treat HIV, according to a study published October 5 in the Journal of the National Cancer Institute.
Breast cancer is one of the most common causes of cancer deaths in the US, with around 39,520 women succumbing to the disease in 2011. HER2-postive breast cancer is known to be more aggressive and less responsive to treatments compared to other types of breast cancer. Nelfinavir has been shown to inhibit the growth of some types of cancers and has been used in clinical trials as either a chemotherapeutic agent or a radiosensitizer for cancer therapy. However, its effect on HER2-positive breast cancer is unknown.
Screening by Johns Hopkins researchers
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