Cancer drug could be repurposed to tackle spinal cord injuries
Early research conducted at the University of Birmingham, UK, shows that the novel ATM blocker AZD1390 can promote regeneration of damaged nerve cells, potentially restoring sensory and motor function after a spinal injury.
The research, published in the journal Clinical and Translational Medicine, used cell and animal models to demonstrate the impact of the oral therapy on the body’s response to DNA damage.
The brain-penetrating candidate is being evaluated under AstraZeneca’s (LSE: AZN) Open Innovations Program, which shares compounds, tools, technologies and expertise with the scientific community.
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