Brazil and Mexico physicians’ preferences on anticoagulants

25 July 2014

Novel oral anticoagulants (NOACs) such asBayer’s (BAYN: DE) Xarelto (rivaroxaban), Boehringer Ingelheim’s Pradaxa (dabigatran etexilate) and Bristol-Myers Squibb (NYSE: BMY)/Pfizer’s (NYSE: PFE) Eliquis (apixaban) are preferred treatments for venous thromboembolism (VTE), atrial fibrillation (AF) and acute coronary syndrome (ACS) among physicians and payers in Brazil and Mexico.

However, according to a new report from Decision Resources Group, there is lower actual NOAC usage than physicians’ ideal prescribing preferences due to limited formulary coverage of NOACs and the high out-of-pocket costs of NOACs relative to conventional anticoagulants in both countries. To obtain formulary coverage, manufacturers of NOACs must demonstrate superior cost-savings with their therapies, which can potentially preclude the additional expenses associated with conventional anticoagulants (such as costs of blood monitoring visits and re-hospitalizations).  

Other key findings from the Emerging Markets Physician and Payer Forum report entitled include:

  • Lack of private outpatient coverage: In Brazil, health maintenance organizations (HMOs) provide inpatient coverage of NOACs but not outpatient coverage. This creates situations in which patients change anticoagulant treatment upon transitioning to the outpatient setting after stays in private hospitals.
  • Variable public coverage of NOACs: In Mexico, the coverage of NOACs varies between the national public healthcare institutions, ranging from requiring out-of-pocket payment to coverage for NOACs for most cardiovascular indications with regulatory approval.
  • Differences in prescribing between the public and private sectors: Patient shares of NOACs are substantially different between the public and private sectors in Brazil and Mexico.

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