Boehringer and Lilly to trial breast cancer drugs combination

13 July 2016

German family-owned major Boehringer Ingelheim and Eli Lilly (NYSE:LLY) have long collaborated in the field of diabetes therapies, but now they are joining forces to test a combination of their respective breast cancer drug candidates.

The companies have announced a new collaboration on a Phase Ib study that will evaluate the safety and tolerability of BI 836845, Boehringer Ingelheim’s insulin-like growth factor (IGF)-1/IGF-2 ligand neutralizing antibody, in combination with abemaciclib (LY2835219), Lilly’s cyclin-dependent kinase (CDK) 4 and 6 inhibitor, in patients diagnosed with HR+/HER2 metastatic breast cancer (mBC).

Based on the Phase Ib trial results, the collaboration has the potential to expand to Phase II studies in patients with HR+/HER2- mBC and other solid tumors. Enrolment is scheduled to begin in late 2016 and Boehringer will be the sponsor of the study program.

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