Bayer hits road block on study aimed at getting additional indication for riociguat

12 May 2016
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Shares of German pharma major Bayer (BAYN: DE) fell a significant 5.35% to 94.65 euros, after the company said that it was halting a mid-stage study with riociguat, putting paid to hopes of an expanded indication for the drug.

Following the recommendation of an independent Data Monitoring Committee (DMC), Bayer is terminating its Phase II study investigating riociguat in patients with pulmonary hypertension associated with idiopathic interstitial pneumonias (PH-IIP) (NCT02138825) with immediate effect.

Riociguat, licensed in the USA under the trade name Adempas, is a stimulator of soluble guanylate cyclase (sGC) and is the only treatment approved in the USA for use in two types of pulmonary hypertension (WHO Groups 1 and 4). Bayer sees the drug as one of its potential growth products for the near future. It is also approved in Europe and Japan.

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