New reminder of challenges of treating addiction with non-opioids
The strain of opioid use disorder (OUD), a chronic neurological disorder characterized by the compulsive, repeated use of opioid drugs, has weighed heavily on many countries in recent years, especially the USA.
But finding an answer by developing non-opioid medications that treat addiction and withdrawal is far from easy, as AstraZeneca (LSE: AZN) recently found out.
The Anglo-Swedish drugmaker has terminated the development of an OUD drug, AZD4041, after the orexin 1 receptor antagonist demonstrated a drug-drug interaction with an antifungal during a Phase II trial.
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