AbbVie in deal with MPP to increase HIV drug access throughout Africa

The Medicines Patent Pool (MPP) today announced a new licensing agreement with US drugmaker AbbVie (NYSE: ABBV), that seeks to address future demands for HIV treatment lopinavir/ritonavir (LPV/r) in South Africa and across Africa.

The agreement has been reached in particular to help ensure sustainability of long-term supply of LPV/r, the most widely used second-line HIV treatment in South Africa and across Africa.    

Under the accord, generic ARV manufacturers, upon obtaining a sublicense from the MPP, will now be able to manufacture and sell generic versions of LPV/r throughout Africa, as well as combinations of ritonavir with other ARVs, such as atazanavir and darunavir, as alternative second-line treatments.

Deal encouraged by South Africa’s government

“This agreement, which the South African government actively encouraged, will significantly help the Ministry of Health to care for its communities living with HIV,” said South African Minister of Health, Aaron Motsoaledi, adding: “LPV/r is critical for second-line treatment in our country and we need to secure supply of the product, especially as treatment needs increase. We welcome the agreement between MPP and AbbVie which will increase the number of manufacturers that can supply the treatment to our people."

The MPP will work to swiftly grant licences to generic manufacturers with stringent regulatory approval.  Those that have already received regulatory approval for these medicines in South Africa will be able to distribute in the country. The South African government will consider applications from other manufacturers that wish to seek approval under its fast track process.  The agreement will also allow global manufacturers to supply LPV/ r and other ritonavir-based combinations to the whole African continent.

"Africa accounts for approximately 90% of the total usage of LPV/r in donor-funded developing countries,” said Greg Perry, executive director of the Medicines Patent Pool. “While many African countries are currently able to purchase generic versions of these medicines from India, this licence will now enable manufacturers in other countries where there are patents, such as China and South Africa, to manufacture LPV/r and other ritonavir-based treatments for Africa, thus broadening the supplier base for the entire continent," he added.

The licence is royalty free and, as is the case for all MPP licences, is non-exclusive and published on the MPP website. The agreement represents the second licence established between MPP and AbbVie. The first agreement was for pediatric formulations of LPV/r signed December last year.