Trodelvy first TROP-2 directed ADC to show significant OS improvement in HR+/HER2- breast cancer
US biotech major Gilead Sciences’ (Nasdaq: GILD) shares were up 4% at $65.48 in early trading today, as it announced statistically-significant and clinically-meaningful results from the second interim analysis of the key secondary endpoint of overall survival (OS) in the Phase III TROPiCS-02 study evaluating Trodelvy (sacituzumab govitecan-hziy) in patients with HR+/HER2- metastatic breast cancer who received prior endocrine therapy, CDK4/6 inhibitors and two to four lines of chemotherapy.
Detailed OS results will be presented at an upcoming medical conference. The safety profile for Trodelvy was consistent with prior studies, and no new safety signals emerged in this patient population.
Gilead gained rights to the TRP-2 targeted antibody drug along with its $21 billion acquisition Immunomedics in 2020.
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