Seattle Genetics and Takeda's Adcetris trial meets endpoints in PTCL

1 October 2018

This morning, Japan’s Takeda Pharmaceuticals (TYO: 4502), in partnership with US biotech firm Seattle Genetics (Nasdaq: SGEN), announced that the Phase III ECHELON-2 clinical trial in frontline CD30-expressing peripheral T-cell lymphoma (PTCL) met its primary endpoint.

Notwithstanding what is clearly positive news, Takeda’s shares fell 2.84% to 4,723 yen in the last hour or so of trading in Tokyo, while Seattle Genetics gained 3.9% to $80.14 by late morning trading.

The trial demonstrated a statistically-significant improvement in progression-free survival (PFS) of Adcetris (brentuximab vedotin) in combination with CHP (cyclophosphamide, doxorubicin, prednisone) versus the control arm, CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone). ECHELON-2 is a global, randomized, double-blind, multicenter trial evaluating Adcetris as part of a frontline combination chemotherapy regimen in patients with previously untreated CD30-expressing PTCL.

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