Neurocrine rockets on positive Phase II data for tardive dyskinesia treatment
Shares of US biotech firm Neurocrine Biosciences (Nasdaq: NBIX) were up almost 80% yesterday after it announced that NBI-98854, a small molecule VMAT2 inhibitor, showed a statistically significant reduction in tardive dyskinesia symptoms, a neurological disorder causing involuntary repetitive body movements.
The Phase IIb Kinect 2 study showed that 67% of the subjects taking NBI-98854 were "much improved" or "very much improved" at week six, compared to only 16% of the placebo subjects. Christopher O'Brien, chief medical officer of Neurocrine Biosciences, said: "The profound response in this Kinect 2 study demonstrates the potential of NBI-98854 as both a safe and highly effective treatment for patients suffering from tardive dyskinesia. It is clear from these results that the use of blinded central AIMS raters coupled with the ability to titrate up to 75 mg of NBI-98854 were both critical to the success of this trial."
Phase III filing expected this year
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