NEJM publishes encouraging study data on Genmab's daratumumab monotherapy in multiple myeloma

27 August 2015

The New England Journal of Medicine has published the full dataset from Danish biotech company Genmab (OMX: GEN) on its Phase I/II study with daratumumab monotherapy in relapsed or refractory multiple myeloma.

The data showed a 36% response rate in the 16 mg/kg group in part 2 of the study, with responses that deepened over time, and 65% of patients in this group that responded to treatment were progression-free twelve months following the start of treatment. Patients receiving 16mg/kg had a median of four prior lines of therapy, and 64% of these patients were refractory to protease inhibitors and immunomodulatory drugs, which are the current standard of care treatments for multiple myeloma.

The 16mg/kg dose was chosen as the dose to be used in future daratumumab trials. The drug is being developed by Janssen Biotech, a unit of Johnson & Johnson (NYSE: JNJ), under an exclusive license from Genmab.

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