Long HCC pipeline marks change for previously stagnant market, says analyst

3 November 2020
globaldata

Despite the high unmet needs within hepatocellular carcinoma (HCC), the market was stagnant from 2007 until 2018, when the FDA approved Eisai’s (TYO: 4523) Lenvima (lenvatinib) in first-line advanced HCC, the most common form of liver cancer.

The current landscape has seen a rapid change. The needs in the HCC space are likely to be met in the near future, as many new therapies entering the market have different mechanisms of action (MOA) and are aiming to meet needs in different treatment settings. The high variety of pipeline products for the early, intermediate and advanced HCC settings brings hope for improvements to the cure rate for early stage HCC and survival for all stages of disease, according to data and analytics company GlobalData.

The result of Phase III IMbrave150 study demonstrated that the combination of systemic bevacizumab therapy Roche (ROG: SIX) subsidiary Genentech’s Avastin and immunotherapy treatment Tecentriq (atezolizumab) for first-line advanced HCC, approved in May 2020, improved overall survival and progression-free survival than the previous standard of care, Bayer’s (BAYN: DE) Nexavar (sorafenib).

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK

Companies featured in this story

More ones to watch >


Today's issue

Company Spotlight





More Features in Biotechnology