Lilly's Retevmo succeeds in lung cancer patients with RET

7 August 2023

US pharma major Eli Lilly (NYSE: LLY) on Friday announced top-line results from the LIBRETTO-431 study evaluating Retevmo (selpercatinib) versus platinum-based chemotherapy plus pemetrexed – with or without Merck & Co’s mega blockbuster PD-1 inhibitor Keytruda (pembrolizumab) – as an initial treatment for patients with rearranged during transfection (RET) fusion-positive advanced or metastatic non-small cell lung cancer (NSCLC).

The US Food and Drug Administration (FDA) granted accelerated approval to Retevmo for adults with locally advanced or metastatic solid tumors with a RET gene fusion in September last year.

Retevmo was brought to Lilly through its $8 billion acquisition of Loxo Oncology in early 2019. The drug generated $192 million in 2022, with the analysts projecting sales will rise to roughly $700 million in 2030.

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