Lilly's donanemab data adds to Alzheimer's optimism

2 December 2022

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It has been a week when Biogen (Nasdaq: BIIB) and Eisai (TYO: 4523) prompted fresh hope in Alzheimer’s by sharing full data on lecanemab, the successor to their failed drug Aduhelm (aducanumab).

The data showed a 27% slowing of cognitive decline with lecanemab, which may not be jaw-dropping but met the trial’s primary endpoint and is a market improvement on Aduhelm, a drug that failed to show a significant clinical effect despite going on to win regulatory approval in the USA.

"These data reinforce our confidence in donanemab's unique mechanism of action based on reductions in key biomarkers of Alzheimer's disease, amyloid plaque and plasma phosphorylated tau"US drugmaker Eli Lilly (NYSE: LLY) has added to the optimistic mood by sharing its own encouraging Alzheimer’s data.

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