Imfinzi combo shines in Phase III stomach cancer trial
A treatment combining AstraZeneca’s (LSE: AZN) immunotherapy Imfinzi (durvalumab) with chemotherapy has significantly reduced the risk of cancer recurrence in patients with early-stage stomach and gastroesophageal junction cancers, according to results from the MATTERHORN Phase III trial.
Researchers found that the regimen, combining Imfinzi with standard chemotherapy before and after surgery, showed a statistically-significant improvement in event-free survival - a measure of how long patients live without their cancer returning or worsening - compared with chemotherapy alone.
Patients receiving the Imfinzi-based treatment were also more than twice as likely to achieve a complete elimination of cancer cells compared with chemotherapy alone (19% versus 7%) in an earlier interim analysis from the trial.
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