ICER weighs up new eczema drugs amid promising but inconclusive evidence

9 July 2021

The USA's Institute for Clinical and Economic Review (ICER) has released an Evidence Report assessing the comparative clinical effectiveness and value of a host of therapies for atopic dermatitis (AD).

These therapies include Pfizer’s (NYSE: PFE) abrocitinib and AbbVie’s Rinvoq (upadacitinib), both of which are effective JAK inhibitors, although safety concerns about drugs in this class remain.

"Dupilumab was a major advance, but it does not work for all patients and new therapies are needed"Another JAK inhibitor, Olumiant (baricitinib) from Eli Lilly (NYSE: LLY) and Incyte (Nasdaq: INCY), and LEO Pharma’s emerging interleukin (IL)-13 inhibitor tralokinumab, are also reviewed and found unlikely to be more efficacious than Dupixent (dupilumab), a treatment from Sanofi (Euronext: SAN) and Regeneron (Nasdaq: REGN) which has demonstrated long-term safety.

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