Discontinuation of dalcetrapib leaves Merck's anacetrapib as the front-running novel CETP inhibitor for dyslipidemia

20 September 2012

The discontinuation of Swiss drug major Roche (ROG: SIX) and Japan Tobacco’s dalcetrapib earlier this year (The Pharma Letter May 8) leaves US pharma giant Merck & Co’s (NYSE: MRK) anacetrapib as the front-runner in the novel CETP inhibitor drug class in the dyslipidemia drug market, according to a new report from health care advisory firm Decision Resources.

However, dalcetrapib’s discontinuation has cast doubt upon the entire CETP inhibitor class and calls into question the high-density lipoprotein cholesterol (HDL-C) hypothesis, which previously came under fire when niacin (Abbott’s Niaspan) failed to show outcomes benefit in the AIM-HIGH clinical trial.

The Pharmacor advisory service entitled Dyslipidemia also finds that key agents that will lose market exclusivity worldwide through 2021 include the statins atorvastatin (Pfizer’s Lipitor; generically available in 2011 in the USA) and rosuvastatin (AstraZeneca/Shionogi’s Crestor), as well as ezetimibe (Merck’s Zetia), ezetimibe/simvastatin (Merck’s Vytorin), Merck’s pipeline agent ezetimibe/atorvastatin and ER niacin.

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK

Companies featured in this story

More ones to watch >


Today's issue

Company Spotlight





More Features in Biotechnology