Deucravacitinib setback seen as bump in blockbuster road by BMS

8 October 2021

US drugmaker Bristol Myers Squibb (NYSE: BMY) has sought to portray a Phase II failure for deucravacitinib as a rare setback for its selective tyrosine kinase 2 (TYK2) inhibitor.

Compared to placebo, deucravacitinib did not meet the primary efficacy endpoint of clinical remission at week 12, nor secondary efficacy endpoints, in the LATTICE-UC trial in ulcerative colitis (UC).

BMS is continuing with another trial of the drug in ulcerative colitis, including with a higher dose, and the company is also investigating its use in multiple immune-mediated diseases, among them psoriasis, psoriatic arthritis, lupus and inflammatory bowel disease.

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