AstraZeneca unimpressed by Ionis' hypercholesterolemia data
Ionis Pharmaceuticals’ (Nasdaq: IONS) shares were down 6.6% pre-market today, after the company released new data on its hypercholesterolemia candidate ION499 that failed to impress its development partner.
UK pharma major AstraZeneca (LSE: AZN) is developing the PCSK9 blocker – also dubbed AZD8233 - under an agreement with California, USA-based Ionis. The companies also have a collaboration for eplontersen, formerly known as IONIS-TTR-LRX, as well as other therapies.
Top-line results from the Phase IIb SOLANO study in patients with hypercholesterolemia demonstrated that 60mg of ION449 (AZD8233), administered monthly, achieved a statistically significant 62.3% (p<0.001) reduction in low-density lipoprotein cholesterol (LDL-C) levels after 28 weeks compared to placebo, meeting the study's primary efficacy endpoint. ION449 was generally safe and well tolerated in this study.
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