ASCO 2024: Gilead and Arcus present anti-TIGIT domvanalimab plus zimberelimab data

3 June 2024

US biotechs Gilead Sciences (Nasdaq: GILD) and Arcus Biosciences (NYSE: RCUS) on Saturday announced longer-term efficacy and safety results from Arm A1 of the Phase II EDGE-Gastric study.

These updated data show consistent objective response rate (ORR) and provide mature progression-free survival (PFS) in patients with locally advanced unresectable or metastatic gastric, gastroesophageal junction or esophageal adenocarcinoma (upper GI cancers). The ongoing, multi-arm, global Phase II EDGE-Gastric study is evaluating the safety and efficacy of various combinations of the Fc-silent anti-TIGIT antibody domvanalimab plus the anti-PD-1 monoclonal antibody zimberelimab and chemotherapy in this patient population.

The results wer presented during the American Society of Clinical Oncology (ASCO) Plenary Series: Rapid Abstract Updates session by Dr Yelena Janjigian, chief, gastrointestinal oncology, Memorial Sloan Kettering Cancer Center, and a principal investigator for the EDGE-Gastric study.

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