Analysis reveals adverse effects of complex cancer therapies

21 November 2022

Over the past two decades, numerous complex cancer therapies called antibody drug conjugates (ADCs) have been tested in clinical trials and approved for use in patients.

Investigators recently performed a comprehensive analysis of multiple scientific databases to outline the potential toxicities associated with these medications. Their findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.

An ADC has a complex structure comprised of an antibody that targets a protein expressed on cancer cells, a toxic compound to kill the targeted cells (also called a payload or warhead), and a linker to join the two. The clinical efficacy and toxicity of ADCs are affected by each component.

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