AbbVie to trial ABBV-399 in combo with Opdivo

22 September 2017

The USA’s AbbVie (NYSE ABBV) is the latest drugmaker to enter into a collaboration to test Opdivo (nivolumab) in combination with its own investigation compound ABBV-399 (telisotuzumab vedotin).

AbbVie’s investigational antibody drug conjugate ABBV-399 and Bristol-Myers Squibb’s (NYSE: BMY) immunotherapy Opdivo will be trialled in c-Met overexpressing non-small cell lung cancer (NSCLC).

A Phase Ib clinical study is underway that includes evaluating the potential of combining Opdivo, which is designed to alleviate immune suppression, with ABBV-399 to explore the tolerability and potential efficacy of the combination in subjects with advanced c-Met overexpressing NSCLC who failed one prior line of chemotherapy. This study could expand into additional solid tumors in the future.

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