Arrowhead’s plozasiran reduced triglycerides by 80%
US biotech Arrowhead Pharmaceuticals (Nasdaq: ARWR) has unveiled highly anticipated pancreatitis results from a late-stage trial of plozasiran, several months after reporting top-line data.
The company noted that the Phase III PALISADE study of investigational plozasiran in patients with familial chylomicronemia syndrome (FCS), a severe and rare genetic disease which currently has no approved treatments in the USA, successfully met its primary endpoint and all multiplicity-controlled key secondary endpoints, including statistically significant reductions in triglycerides (TGs), apolipoprotein C-III (APOC3), and the incidence of acute pancreatitis (AP).
These data were presented in a late-breaking oral presentation at the European Society of Cardiology (ESC) Congress 2024. With today being a public holiday in the USA, there was no investor reaction to the news.
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