Antisense leukemia drug enters trials
Genta has started two new clinical trials of its flagship antisensedrug, Genasense, in patients with acute myeloid leukemia and chronic lymphocytic leukemia, respectively. Genasense blocks Bcl-2, a protein that is overexpressed in many forms of leukemia and is considered a major factor contributing to resistance of these diseases to standard treatment.
The CLL study will look at Genasense treatment as a monotherapy, while the AML trial will investigate the drug in combination with Wyeth-Ayerst's Mylotarg (gemtuzumab ozogamicin). Both trials will be conducted at the MD Anderson Cancer Center in the USA and enroll patients who have failed first-line therapy for these forms of leukemia.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
Free
7 day trial access
- All the news that moves the needle in pharma and biotech
- Exclusive features, podcasts, interviews, data analyses and commentary from our global network of life sciences reporters.
- Receive The Pharma Letter daily news bulletin, free forever.
Become a subscriber
£820
Or £77 per month
- Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
- Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
- Daily roundup of key events in pharma and biotech.
- Monthly in-depth briefings on Boardroom appointments and M&A news.
- Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Today's issue
Company Spotlight
Copyright © The Pharma Letter 2024 | Headless Content Management with Blaze