Mirati falls, as Phase III sitravatinib combo trial flops

25 May 2023
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Shares of US oncology drugmaker Mirati Therapeutics (Nasdaq: MRTX) closed down 4% on Wednesday and were a further 8.7% lower at $40.01 in pre-market activity today, after it revealed that the SAPPHIRE study did not meet its primary endpoint of overall survival (OS) at the final analysis.

SAPPHIRE is a Phase III study evaluating sitravatinib in combination with nivolumab (Bristol Myers Squibb’s [NYSE: BMY] blockbuster brand Opdivo) versus docetaxel in patients with second or third line advanced non-squamous non-small cell lung cancer (NSQ-NSCLC) who progressed on prior therapy with chemotherapy and immune checkpoint inhibitor therapy. The company plans to disclose the study data at a future date.

Principal Investigators will be given the option to continue therapy for patients who are experiencing clinical benefit and would like to remain on treatment.

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